The Melanoma Letter Spring 2012, Vol. 30, No. 1

This issue marks the 30th anniversary of The Melanoma Letter. It’s an occasion to reflect on the sweeping changes in melanoma prevention, diagnosis, and treatment since the publication began, which have been reflected in its pages.In our lead article, Drs. Michael Postow and Jedd Wolchok explore the great promise ipilimumab holds for so many patients with advanced melanoma. They describe the relative rapidity with which immune checkpoint blockade was developed and brought to the clinic with ipilimumab, and expertly summarize the clinical considerations with this drug and its limitless potential, especially in combination with other agents.In our second story, Dr. Sanjiv Agarwala reviews the gradual evolution of intralesional therapy for cutaneous melanoma metastases and describes the recent resurgence of Rose Bengal (PV-10) as an intralesional agent. 

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